NCT05726695

The Use of Blood Biochemical Markers for Diagnostics of Heart Muscle Diseases

The Use of miRNA Detection for Diagnostics of Cardiovascular Diseases

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: University Hospital Ostrava · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to determine the analytical characteristics of the microRNA enzymatic immunoassay (miREIA) method and to determine various relations among miRNA biomarkers and heart failure (HF) with reduced ejection fraction(HFrEF). The investigators assume that there are correlations between levels of selected miRNA and HFrEF. These correlations provide information to formulate pathophysiological conclusions, which will significantly contribute to early diagnostics and also the treatment of this disease.

Detailed description

Heart failure presents a significant diagnostic and treatment problem. The mortality in the Czech Republic related to this condition is high. The current treatment strategy consists of the administration of medication to patients, in order to attenuate the clinical manifestations of the disease and to influence the overall survival of patients suffering from this condition. Another treatment option is a mini-invasive procedure, with implantation of a pacemaker with biventricular stimulation, or transplantation of the heart. Despite these treatment options, the mortality of patients due to heart failure remains high, and new approaches are being studied for the diagnostics and treatment of heart failure. Factors that may play an important role in earlier diagnostics are miRNA. These molecules are located in the circulating blood. They are being described as suitable prognostic markers of heart failure, which may contribute to earlier diagnostics and bring a better understanding of processes going on in the human body. In the study, the authors will take blood samples in order to analyze the presence of miRNA. These levels of miRNA will be compared with heart ultrasound parameters of HF patients and healthy control subjects.

Conditions

• Heart Failure
• Heart Dilation
• Left Ventricular Hypertrophy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	microRNA test	Laboratory analysis for the detection of microRNA in blood samples.
DIAGNOSTIC_TEST	Heart ultrasound examination	Heart ultrasound examination will be performed as a standard cardiology examination.

Timeline

• Start date: 2018-06-01
• Primary completion: 2022-12-31
• Completion: 2023-12-31
• First posted: 2023-02-14
• Last updated: 2023-02-14

Locations

1 site across 1 country: Czechia