NCT05724290

Mechanism of EGR2 in Allergic Rhinitis

The Regulatory Mechanism of EGR2 Mediated by miR-150-5p on Allergic Rhinitis

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 3 (estimated)
• Sponsor: Zu-xia Ma · Academic / Other
• Sex: All
• Age: 16 Years – 76 Years
• Healthy volunteers: Not accepted

Summary

EGR2 may be a target for the treatment of nasal polyps.

Detailed description

There is much debate about the etiology of nasal polyps, so the pathogenesis of nasal polyps still needs to be clarified. Surgery for noninflammatory nasal polyps may be better control, but surgery is not effective for recurrent sinusitis and nasal polyps. Therefore, more research is needed to determine the best targeted therapy for nasal polyps. We found that EGR2 expression was upregulated in CRSwNP patients with allergic rhinitis.In addition, the expression of EGR2 in CRSwNP mucosa was significantly higher than that in the control group, and the expression of EGR2 in CRSwNP with allergic rhinitis was higher than that in CRSwNP without allergic rhinitis. EGR2 may be involved in the pathogenesis of nasal polyps, and may also be related to the severity and recurrence of nasal polyps. EGR2 may be a target for the treatment of nasal polyps.

Conditions

• Rhinitis, Allergic

Interventions

Type	Name	Description
GENETIC	EGR2	We investigated the expression of EGR2 in patients with nasal polyps through immunohistochemistry.

Timeline

• Start date: 2023-01-30
• Primary completion: 2023-02-01
• Completion: 2023-05-05
• First posted: 2023-02-13
• Last updated: 2023-02-13

Locations

1 site across 1 country: China