NCT05723276

Psilocybin in Functional Neurological Disorder

Probing the Functional Magnetic Resonance Imaging Response to Psilocybin in Functional Neurological Disorder (PsiFUND)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to learn about the brain network response in people who have functional neurological disorder who are administered with a single dose of the psychedelic psilocybin with therapeutic support. The main question it aims to answer is: Can the default mode network, a brain network thought to be relevent in FND, be modified by the administration of psilocybin based on functional magnetic resonance imaging before and after the dose?

Conditions

• Functional Neurological Disorder

Interventions

Type	Name	Description
DRUG	Psilocybin	Psilocybin 25mg PO

Timeline

• Start date: 2024-02-14
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2023-02-10
• Last updated: 2026-04-17

Locations

1 site across 1 country: United Kingdom