NCT05722873

The Metabolic Effects of Intermittent Fasting

The Effects of Fasting on Reprogramming of Lipid Metabolism and Bone Metabolism

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 21 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Caloric restriction has beneficial metabolic effects in humans including weight loss and improvement in blood pressure and lipid levels. Intermittent fasting has emerged as a popular alternative to caloric restriction as it does not require daily adherence to a dietary protocol, but whether the benefits of fasting protocols are dependent on weight loss is not known. In this study, the investigators will explore the metabolic effects of fasting and evaluate whether these effects, including negative effects on bone metabolism, are independent of weight loss.

Conditions

• Normal and Overweight Individuals at High-risk of Diabetes

Interventions

Type	Name	Description
BEHAVIORAL	Fasting arm	Study participants will fast one day per week for 12 weeks
BEHAVIORAL	Weight maintenance	Study participants will be counseled to maintain body weight
BEHAVIORAL	Counseling	Study participants will be counseled on optimal diet and activity recommendations for maintaining/achieving a normal BMI

Timeline

• Start date: 2023-10-25
• Primary completion: 2028-06-30
• Completion: 2028-06-30
• First posted: 2023-02-10
• Last updated: 2025-08-07

Locations

1 site across 1 country: United States