NCT05719922

The ADAPTation to Therapeutic Resistance Training (ADAPT) Study

Low-load Blood Flow Restriction Exercise Versus Conventional Heavier Load Resistance Training Exercise in UK Military Personnel With Persistent Knee Pain: A Multi-centre Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Defence Medical Rehabilitation Centre, UK · Other Government
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

In 2018, the Academic Department of Military Rehabilitation (ADMR) published a pilot randomised controlled trial (RCT), demonstrating the feasibility and acceptability of integrating twice-daily blood flow restriction (BFR) training into a busy residential care setting. Following its publication was a guidance note written by the Directorate of Defence Rehabilitation restricting the implementation of BFR training until more evidence can be provided to support its efficacy. This research trial is a fully-powered, multi-centre RCT investigating the efficacy and biological mechanism underpinning BFR therapy in UK military personnel with lower-limb musculoskeletal injury (specifically, persistent anterior knee pain) during residential rehabilitation. This study will aim to optimise both the rehabilitation outcome and improve the time-and cost-effectiveness of the service delivered across UK Defence Rehabilitation and beyond. Results will provide insight and knowledge to the clinical and scientific community to not only those embedded within Defence Rehabilitation, but also those working in civilian sector organisations and professional sport in the UK and abroad.

Conditions

• Musculoskeletal Injury
• Muscle Weakness

Interventions

Type	Name	Description
OTHER	Resistance Training	Comparing two different exercise-based treatment methodologies on the clinical outcomes of individuals with persistent knee pain.

Timeline

• Start date: 2022-12-01
• Primary completion: 2024-08-31
• Completion: 2024-08-31
• First posted: 2023-02-09
• Last updated: 2023-02-09

Locations

6 sites across 1 country: United Kingdom