NCT05717127

Metabolic Impact of Intermittent Fasting in Early Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: Mount Sinai Hospital, Canada · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

One known cause of type 2 diabetes (T2DM) is beta-cell dysfunction, which refers to the inability of the beta-cells of the pancreas to produce enough insulin for the body's needs. Unfortunately, no anti-diabetic medication or lifestyle intervention has been shown to prevent the worsening of beta-cell function over time. Interestingly, however, intermittent fasting (IF) - where no food is consumed over a period of time - has been shown to promote weight loss and improve cardio-metabolic function. In individuals with T2DM, it is also been shown to improve glycemic control (i.e. reduce the sugar levels). While no research has studied whether IF can improve pancreatic beta-cell function, the positive metabolic effects suggest that it could provide some benefit. The current study will evaluate whether IF can improve pancreatic beta-cell function in individuals with early T2DM.

Conditions

• Diabetes Mellitus, Type 2
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Time restricted feeding	Restricted feeding with 20 hours of fasting and a 4 hour window of feeding (between 4 and 8 PM or between 5 to 9 PM).
BEHAVIORAL	Standard lifestyle	Standard lifestyle recommendations

Timeline

• Start date: 2021-09-01
• Primary completion: 2023-06-01
• Completion: 2023-06-01
• First posted: 2023-02-08
• Last updated: 2025-10-03

Locations

1 site across 1 country: Canada