NCT05714618

MR Evidence of Cardiac Inflammation Post-Stroke

Magnetic Resonance Imaging Evidence of Cardiac Inflammation Post-Stroke

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 44 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left (n=22) MCA territories and 24 control patients with acute focal neurological symptoms but no evidence of acute brain infarct on DWI-MRI.

Detailed description

The present study is an investigator-initiated, single-center, prospective cohort study. The study aims to enroll 44 patients with acute/subacute middle cerebral artery (MCA) ischemic stroke. The investigators will compare inflammatory markers among 44 patients with MCA ischemic stroke within 10 days post-stroke vs. 60±15 days post-stroke. Other measures to be determined at both time points include B-Type Natriuretic Peptide and systemic inflammatory markers.

Conditions

• Stroke, Ischemic
• Inflammation
• Myocardial Injury

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Gadolinium-enhanced cardiac MRI	Cardiac magnetic resonance imaging (MRI) with a protocol designed to measure myocardial inflammation and fibrosis.
DIAGNOSTIC_TEST	B Natriuretic Peptide	Measurement of B Natriuretic Peptide on patients' blood samples at 10 and 60+/-15 days.
DIAGNOSTIC_TEST	Systemic inflammatory markers	Measurement of a panel of 92 systemic inflammatory markers on patients' blood samples at 10 and 60+/-15 days.

Timeline

• Start date: 2021-10-01
• Primary completion: 2025-06-16
• Completion: 2025-12-31
• First posted: 2023-02-06
• Last updated: 2024-09-20

Locations

1 site across 1 country: Canada