NCT05713734

Bleeding of Unknown Cause: a Swiss Case-control Study

Bleeding of Unknown Cause, Insight Into a Multifactorial Bleeding Disorder: a Swiss Case-control Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.

Detailed description

Patients with bleeding of unknown cause are included. At baseline, blood will be drawn to evaluate the hemostatic profile. Findings are compared to a control group of healthy individuals. Patients and controls are followed for 3 years.

Conditions

• Bleeding Disorder

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Thrombin generation	Measurement of thrombin generation by ST Genesia
DIAGNOSTIC_TEST	Fibrinolysis	Measurement of fibrinolysis by Lysis Timer
DIAGNOSTIC_TEST	Fibrin clot structure	Measurement of fibrin polymerisation and permeability
DIAGNOSTIC_TEST	Coated platelets	Measurement of coated platelets by flow cytometry

Timeline

• Start date: 2023-04-01
• Primary completion: 2026-04-01
• Completion: 2027-04-01
• First posted: 2023-02-06
• Last updated: 2024-12-16

Locations

7 sites across 1 country: Switzerland