NCT05712733

Cholecystitis From a Microbiological and Histopathological Perspective

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Organkirurgisk afdeling, sygehus lillebælt, Kolding · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to investigate the presence of bacteria in the gallbladder wall and the bile in patients undergoing cholecystectomy, to determine if the standard empirical antibiotic treatment used currently is effective against the most common pathogens.

Detailed description

The investigators will compare two groups of patients; patients with acute calculous cholecystitis undergoing acute laparoscopic cholecystectomy and patients without cholecystitis undergoing elective laparoscopic cholecystectomy. Secondly, the investigators wish to investigate if the presence of bacteria correlates with the grade of inflammation, and whether this can predict when cholecystitis is caused by infection. In a clinical setting, this can provide important knowledge regarding the choice of antibiotics currently used to treat and prevent infection in the gallbladder. The investigators will conduct two studies, one investigating the bacteria in bile and in the gallbladder wall and the resistens of the bacteria to antibiotics and another study investigating the histopathology of the gallbladder wall to see if the bacteria present is the cause of inflammation or an actual infection.

Conditions

• Calculous Cholecystitis
• Antibiotic Resistant Infection
• Gallbladder Inflammation

Interventions

Type	Name	Description
OTHER	Microbiological and histopathological investigation of bile and gallbladder wall specimens.	Bile and gallbladder wall specimens will be taken from all patients included in the study. The material will be sent for microbiological and histopathological investigation.

Timeline

• Start date: 2023-04-01
• Primary completion: 2025-06-01
• Completion: 2025-10-01
• First posted: 2023-02-03
• Last updated: 2024-04-15

Locations

1 site across 1 country: Denmark