NCT05708599

A Study to Compare Tissue and Liquid Biopsies in People With Different Types of Cancer

Longitudinal Liquid Biopsy Study Without an Investigational Medicinal Product in Patients With Non-Small Cell Lung Cancer (NSCLC) Including Squamous Cell Carcinoma, Adenocarcinoma and Large Cell Carcinoma, Colorectal Carcinoma (CRC) and Pancreatic Ductal Adenocarcinoma (PDAC) to Evaluate Novel Blood-based Biomarkers for Use in Early Clinical Development

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: Boehringer Ingelheim · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In study, liquid biopsy samples will be obtained from non-small cell lung cancer (NSCLC) including Squamous cell carcinoma, Adenocarcinoma and large cell carcinoma, colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC) patients who undergo treatment according to established standards of care (SoC) at the University Hospital Schleswig-Holstein (UKSH). This study will observe the overall Variant Allele Frequency (VAF) of circulating tumour Desoxyribonucleic acid (ctDNA) levels over the patient therapeutic treatment course and will correlate these findings with tumour response as well as Kirsten rat sarcoma viral oncogene homolog (KRAS)mutation status.

Conditions

• Non-Small-Cell Lung Carcinoma
• Colorectal Cancer
• Pancreatic Ductal Adenocarcinoma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Liquid biopsy	Liquid biopsy

Timeline

• Start date: 2023-03-01
• Primary completion: 2027-02-08
• Completion: 2027-02-08
• First posted: 2023-02-01
• Last updated: 2026-01-21

Locations

1 site across 1 country: Germany