NCT05706636

T Central Memory Cells in Early Localized Non-Segmental Vitiligo

T Central Memory Cells in Early Localized Non-Segmental Vitiligo and the Effect of Treatment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 12 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after treatment in comparison to healthy controls. This, in turn, would provide insights regarding the role of TCMs in vitiligo and the role of early treatment in halting disease progression and autoimmune memory formation that accounts for high recurrence rate of vitiligo

Detailed description

Assessing the level of circulating TCMs (CD8+ CD3+ CCR7+ CD45RO+ cells) in early localized vitiligo cases where samples will be processed and stained for CD8, CD3, CCR7, . CCR7, CD45R. Multi-parametric flow cytometry will be used to quantify CD3+ve, CD8+ve, CCR7+ve, CD45RO+ve TCM cells percentage, which will be expressed as a percentage from the total lymphocyte gate. This will be done prior to treatment and after treatment and will be compared to healthy controls.

Conditions

• Vitiligo

Interventions

Type	Name	Description
DRUG	oral mini pulse	5mg / week oral dexamethasone
DRUG	Topical cream	topical fluticasone cream for body lesions and topical tacrolimus for face lesions
DEVICE	targeted phototherapy	twice weekly targeted excimer light sessions

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-12-01
• Completion: 2025-04-15
• First posted: 2023-01-31
• Last updated: 2025-04-25

Locations

1 site across 1 country: Egypt