NCT05705596

Impact of Hesperetin in Combination With Sucrose on Energy Metabolism

Einfluss Des süßmodulierenden Polyphenols Hesperetin in Kombination Mit Saccharose Auf Die Blutglukose-Regulierung Und Energieaufnahme in Abhängigkeit Der Süßwahrnehmung

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: University of Vienna · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this cross-over intervention study is to investigate the influence of the sweet-modulating substance hesperetin in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution on markers of energy metabolism.

Detailed description

The study is designed as a randomised cross-over intervention study with two arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers. To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and circulating extracellular vesicles and their miRNA composition will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.

Conditions

• Blood Glucose Fluctuations
• Hunger

Interventions

Type	Name	Description
OTHER	Sucrose	10% sucrose corresponding to a regular soft drink
DRUG	Hesperetin	increases sweetness of 7% sucrose solution to match sweetness of 10% sucrose solution

Timeline

• Start date: 2023-01-31
• Primary completion: 2023-06-30
• Completion: 2023-11-15
• First posted: 2023-01-31
• Last updated: 2023-11-28

Locations

1 site across 1 country: Austria