NCT05701696

The Relationship Between Neuropathic Complaints and Central Sensitization in Fibromyalgia

Investigation of the Relationship Between Neuropathic Complaints and Central Sensitization in Patients With Fibromyalgia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 111 (estimated)
• Sponsor: Marmara University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: —

Summary

Fibromyalgia (FM) is the prototype of a group of diseases known as central sensitivity syndromes, whose relationship with pain sensitization is well defined. Central sensitization (CS) is also one of the mechanisms involved in the pathophysiology of neuropathic pain. Neuropathic pain, which is a common complaint in FM patients, is likely to be one of the clinical manifestations of central sensitization. Therefore, in this study, it was aimed to investigate the relationship between CS and neuropathic pain.

Detailed description

The term central sensitization (CS) was first used by Wolf in 1988 and explained as an increase in pain sensitivity with the amplification of neuron-derived signals in the central nervous system. Fibromyalgia (FM) is a disease characterized by chronic widespread pain and its etiology and pathophysiology are still unknown. It is considered to be the main member of the CS related disease group known as central sensitivity syndromes with impaired pain regulation. In various studies, hyperalgesia and allodynia, which are accepted as objective findings of CS in pain sensitization. In addition to widespread body pain, neuropathic pain is one of the common symptoms in FM, and various studies have shown a significant increase in neuropathic pain in FM patients compared to healthy controls. It is known that CS is one of the basic mechanisms in the etiopathogenesis of neuropathic pain as well as its role in FM. In a study of FM patients, painDETECT and S-LANSS scores were found to be correlated with CSI scores, and the authors emphasized the relationship between pain sensitization and neuropathic complaints in these patients. CS seems likely to be one of the neuropathic pain mechanisms in FM patients, and the available data seem insufficient to draw a definitive conclusion. From this point of view, in this study, it was aimed to investigate the relationship between the presence and severity of CS and the neuropathic pain component of the disease in patients with FM.

Conditions

• Central Sensitisation
• Fibromyalgia
• Neuropathic Pain

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Central sensitization inventory	Standardized questionnaire to determine the level of central sensitization. Patients with a score of 40 and above are considered to have central sensitization.
DIAGNOSTIC_TEST	Widespread pain index	Total the number of painful body areas
DIAGNOSTIC_TEST	Symptom severity scale	The sum of the fatigue, waking unrefreshed and cognitive symptoms and the extent of somatic symptoms
OTHER	Fibromyalgia impact questionnaire	A tool to assess health status in fibromyalgia
DIAGNOSTIC_TEST	Hospital Anxiety and Depression Scale	An instrument for detecting depression and anxiety
DIAGNOSTIC_TEST	Self-Leeds Assessment of Neuropathic Symptoms and Signs	An instrument used to identify pain of neuropathic origin

Timeline

• Start date: 2023-01-16
• Primary completion: 2023-08-30
• Completion: 2023-11-30
• First posted: 2023-01-27
• Last updated: 2023-02-28

Locations

1 site across 1 country: Turkey (Türkiye)