Trials / Terminated

TerminatedNCT05701371

BACTERIA ISOLATION FROM STOOLS COLLECTED FROM CENTENARIANS PEOPLE

NON-INTERVENTIONAL STUDY, MULTICENTRIC STUDY, AIMING AT CONSTITUTING A BIOLOGICAL SAMPLES COLLECTION FROM CENTENARIAN PEOPLE

Status: Terminated
Phase: —
Study type: Observational
Enrollment: 20 (actual)

Sponsor: Bioaster · Academic / Other
Sex: Female
Age: 95 Years
Healthy volunteers: Accepted

Summary

The compositional analysis of commensal bacterial populations collected from a variety of clinical samples has been recently made possible with the availability of Next Generation Sequencing (NGS) technologies. The term 'next-generation probiotics' (NGP) is now widely used to describe these commensal species of potential health interest. However, this approach is still hampered by the fact that there are usually few or even no strains available for a number of commensal species. In this context, BIOASTER has developed a specific technological process based on flow cytometry analysis and then sorting under strictly anaerobic conditions to target and cultivate commensal species of interest. The review of the literature shows that certain species present among centenarians have an interest in maintaining the longevity of these individuals. Numerous studies have shown that the intestinal microbiota of centenarians presents a greater diversity compared to groups of younger subjects as well as an enrichment in certain bacteria such as Akkermansia and Christensenella. The goal of this observational study is to constitute a biological samples collection from centenarian people, to proceed with the isolation of beneficial commensal strains such as Faecalibacterium prausnitzii, Akkermansia muciniphila and Oscillospiraceae, in a non-limitative way. Elderly and centenarian people will be recruited in nursing home among the Gerontopole of "Ile de France" network. Blood (serum + TruCulture tubes) and stools will be collected from each subject.

Conditions

Healthy Aging

Interventions

Type	Name	Description
OTHER	Biological samples collection	blood drawing + feces collection in a dedicated device

Timeline

Start date: 2023-06-06
Primary completion: 2023-10-18
Completion: 2023-10-18
First posted: 2023-01-27
Last updated: 2024-03-19

Locations

1 site across 1 country: France

Source: ClinicalTrials.gov record NCT05701371. Inclusion in this directory is not an endorsement.