NCT05701150

AIO-BNHO Comprehensive Clinico-genomics Database Network - AIO-BNHO CONNECT

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: AIO-Studien-gGmbH · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

National, retro- and prospective, observational, multicenter clinical research platform to connect clinical and genomic data of patients with advanced (locally advanced, inoperable, or metastatic) solid tumors (excluding NSCLC, SCLC, and mesothelioma) with results from multi-gene next-generation sequencing (NGS) panels (\>30 genes)

Detailed description

The AIO-BNHO CONNECT research platform is a clinic-genomic database collecting data on NGS results and corresponding clinical outcomes in patients with advanced solid tumors (excluding NSCLC, SCLC, and mesothelioma). Data of deceased patients will be included. The platform will provide insight into the current state of precision oncology in Germany by compiling real-world data encompassing a broad spectrum of care providers including but not limited to practice-based oncologists, community hospitals, and university hospitals. The platform also comprises a decentral tissue repository with clinically annotated tumor specimens retrieved within routine clinical care that can be used in future collaborative research projects.

Conditions

• Advanced Solid Tumor

Interventions

Type	Name	Description
OTHER	Minimal documentation	Minimal data documentation only of patients without targeted therapy based on NGS results
OTHER	Extended documentation	Extended data documentation of patients with targeted therapy based on NGS results

Timeline

• Start date: 2022-12-08
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2023-01-27
• Last updated: 2025-02-17

Locations

3 sites across 1 country: Germany