NCT05700916

Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity

Evaluation of Milk Polar Lipids on Lipoprotein Metabolism, Inflammation, and Gut Microbiota in Dyslipidemic Adults With Abdominal Obesity

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 130 (estimated)
• Sponsor: University of Connecticut · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The major objective of this project is to examine whether daily consumption of milk polar lipids (MPLs) influences cardiometabolic risk factors.

Detailed description

The investigators will conduct a randomized, double-blind, controlled, parallel, intervention study in dyslipidemic adults with abdominal obesity (n = 130). Participants will consume either a control dairy beverage (n = 65) or an MPL-rich dairy beverage (n = 65) for 8 weeks. The investigators plan to evaluate the following 4 specific objectives: 1. Determine the effects of MPLs on serum lipid concentrations and other cardiometabolic risk factors. 2. Evaluate the effects of MPLs on systemic biomarkers of low-grade inflammation. 3. Examine the effects of MPLs on lipoprotein metabolism and lipoprotein particle characteristics. 4. Evaluate the effects of MPLs on gut microbiota, gut permeability markers, and fecal lipids.

Conditions

• Dyslipidemias
• Obesity

Interventions

Type	Name	Description
DRUG	Milk Polar Lipid-Rich Dairy Powder	Effects of the addition of 6.5 g of milk polar lipids to dairy powder.
DIETARY_SUPPLEMENT	Dairy Powder	Effects of dairy control powder

Timeline

• Start date: 2023-10-20
• Primary completion: 2026-05-01
• Completion: 2026-06-01
• First posted: 2023-01-26
• Last updated: 2025-12-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study