NCT05699200

A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection

Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Conditions

• Spontaneous Coronary Artery Dissection
• Healthy

Interventions

Type	Name	Description
OTHER	Arterial Tonometry	We will measure arterial stiffness using arterial tonometry.
DIAGNOSTIC_TEST	Echocardiogram	We will collect limited ultrasound images of the heart.
DIAGNOSTIC_TEST	Carotid Ultrasounds	We will perform ultrasound imaging of the carotid artery.
DIAGNOSTIC_TEST	Elastography	We will measure the elastic properties of the arteries using elastography.
OTHER	Ankle-Brachial Index	We will measure the ankle-brachial index to assess peripheral artery blood flow.
OTHER	Microneurography with sympathoexcitatory maneuvers	We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Timeline

• Start date: 2023-06-01
• Primary completion: 2027-08-01
• Completion: 2027-08-01
• First posted: 2023-01-26
• Last updated: 2025-06-12

Locations

1 site across 1 country: United States