NCT05699044

Screening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker Implantation

Prevalence, Characteristics and Prognosis of Transthyretin Amyloidosis in Patients With New-onset Advanced AV-block - A National Screening Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 170 (estimated)
• Sponsor: Steen Hvitfeldt Poulsen · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators will nationally investigate the prevalence of Transthyretin Amyloidosis wildtype (ATTRwt) in patients of ≥ 65 years with left ventricular hypertrophy who present with high degree atrioventricular block (AV-block) and are admitted for pacemaker implantation. The investigators aim to characterize the group of patients with positive screening of ATTR and compare the ATTRwt disease stage at time of diagnosis for patients identified with ATTR at screening with a control group of routinely clinically diagnosed ATTRwt patients.

Conditions

• Amyloid Cardiomyopathy
• Block, AV

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Amyloidosis screening (bloodtest, DPD-scintigraphy, potentially endomyocardial biopsy)	Bloodtest: Troponin I, NT-pro-BNP, electrolyte status, renal function, kampda/lambda free chain + ratio, M-komponent. DPD-scintigraphy. (Echocardiography)

Timeline

• Start date: 2022-10-01
• Primary completion: 2025-08-01
• Completion: 2025-10-01
• First posted: 2023-01-26
• Last updated: 2023-06-02

Locations

1 site across 1 country: Denmark