NCT05691205

Identifying Optimal PEEP After Lung Transplantation

Identifying the Optimal Positive End-Expiratory Pressure Level to Ventilate Patients After Bilateral Lung Transplantation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: Policlinico Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Lung Transplantation (LuTX) is the curative treatment for selected patients with end-stage lung disease. Primary Graft Dysfunction (PGD), a specific form of respiratory failure occurring within the first 72 hours after graft reperfusion, represents the most common complication after LuTX. Actual recommendation regarding management of mechanical ventilation of the lung graft immediately after LuTX are based only on opinion experts and not on clinical trials. Optimization of Positive End-Expiratory Pressure might contribute to both prevention and treatment of PGD. In this interventional single-center non-pharmacological study (with medical device), in the immediate postoperative period of patients who are undergone LuTX, we will evaluate the effects of varying levels of PEEP upon: - lung and chest wall mechanics, - intrapulmonary shunt fraction; - distribution of ventilation and perfusion; - gas exchange. The final aim is to find the optimal level of PEEP in this patient's cohort

Conditions

• Lung Transplant; Complications
• Primary Graft Dysfunction

Interventions

Type	Name	Description
OTHER	PEEP	After a recruitment maneuver three levels of PEEP (14\>10\>6cmH2O) will be tested

Timeline

• Start date: 2023-01-31
• Primary completion: 2024-12-31
• Completion: 2025-03-15
• First posted: 2023-01-19
• Last updated: 2025-04-02

Locations

1 site across 1 country: Italy