NCT05690087

Lidocaine Infusion on Optic Nerve Sheath Diameter in Laparoscopic Hysterectomy in Trendelenburg Position

Effect of Systemic Lidocaine Infusion on Optic Nerve Sheath Diameter in Patients Undergoing Laparoscopic Hysterectomy in Trendelenburg Position

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: Female
• Age: 35 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

We hypothesize that intravenous lidocaine infusion may have beneficial effect to patients undergoing laparoscopic surgeries in Trendelenburg position by preventing ICP elevation.

Detailed description

Lidocaine use, both intravenous (IV) and laryngotracheal (LT), has been reported to blunt the ICP elevations during intubation. Also, Lidocaine injected IV has been shown in models to induce cerebral vasoconstriction leading to a decrease in cerebral blood volume and thus ICP. Furthermore, IV lidocaine leads to sodium channel inhibition and thus a reduction in cerebral activity and metabolic demands, as well as excitotoxicity, leading to a potential ICP reduction effect.

Conditions

• Lidocaine
• Optic Nerve Sheath Diameter
• Laparoscopic Hysterectomy
• Trendelenburg

Interventions

Type	Name	Description
DRUG	Lidocaine	intravenous lidocaine 2% bolus of 1.5 mg/kg over 5 min before induction of anesthesia followed by lidocaine infusion at 1.5 mg/kg/h intraoperatively until desufflation
DRUG	sodium chloride 0.9% solution	intravenous sodium chloride 0.9% solution volume matched bolus and infusion.

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2023-01-19
• Last updated: 2024-01-03

Locations

1 site across 1 country: Egypt