NCT05686772

Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis

A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 520 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis. The main questions to be answered are: 1. What is the incidence of problem gambling in this population? 2. What are the predictors of problem gambling in this population? To do so, putative predictors of problem gambling will be analyzed using Cox regression models: * Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment); * Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders); * Antipsychotic use (first/second-generation, third-generation \[aripiprazole, brexpiprazole, cariprazine\]); * Prior gambling history.

Detailed description

All Cox regression models will be adjusted for site-effect. Further multivariable models will be constructed to examine the association between antipsychotic use (as continuous exposure) and incident PBG using the directed acyclic graphs approach to adjust for confounders.

Conditions

• Gambling Disorder
• Psychotic Disorders

Interventions

Type	Name	Description
DRUG	Antipsychotic use	Use of first/second generation antipsychotics, use of third-generation antipsychotics, use of aripiprazole specifically
OTHER	Psychiatric comorbidities	Substance use disorders, cluster B personality disorders, anxiety disorder, major depressive disorder, attention-deficit/hyperactivity disorder, tobacco smoking
OTHER	Sociodemographics/socioeconomic status	Age, gender identity, ethnicity, highest educational attainment, employment, at school, homelessness, in a relationship
OTHER	Gambling history	Non-problematic gambling at the time of admission and/or previous 12 months
OTHER	Clinical variables	Main psychiatric diagnosis, history of psychiatric hospitalizations, severity of illness (CGI-S), functioning (SOFAS), concomitant psychotropic medications use

Timeline

• Start date: 2019-11-01
• Primary completion: 2023-05-01
• Completion: 2023-05-01
• First posted: 2023-01-17
• Last updated: 2025-05-28

Locations

2 sites across 1 country: Canada