NCT05683873

Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 130 (estimated)
• Sponsor: Centre Hospitalier Universitaire Dijon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke. It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy). The research is interventional because a biological blood test will be performed, as well as a heart rhythm recording and several cardiac echograms during the hospitalization of the participants and during the follow-up consultation scheduled 4 to 6 months after the stroke. A total of 130 stroke patients will participate in this study. Participation includes 4 visits: * Inclusion visit (within 24 hours of the first stroke symptoms) * visit 1 (within 24 to 72 hours of stroke) * visit 2 (within 48 hours of visit 1) * Visit 3 (approximately 4-6 months post-stroke)

Conditions

• Ischemic Stroke

Interventions

Type	Name	Description
PROCEDURE	Electrocardiogram	Inclusion visit, V1, V2 and V3
PROCEDURE	transthoracic echocardiography	V1, V2 and V3
BIOLOGICAL	standard biology	Inclusion visit
BIOLOGICAL	determination of serum GDF-15, osteoprotegerin and ST-2	Inclusion visit, V1, V2 and V3
BIOLOGICAL	Ultrasensitive Troponin-Ic	Inclusion visit, V1, V2 and V3
OTHER	Collection of clinical and radiological data	Inclusion visit, V1 and V3: clinical data only V2: clinical and radiological data
OTHER	72-hour continuous Holter-ECG recording	V1

Timeline

• Start date: 2023-02-13
• Primary completion: 2027-08-01
• Completion: 2027-08-01
• First posted: 2023-01-13
• Last updated: 2025-01-28

Locations

1 site across 1 country: France