NCT05681611

Effect of Rocuronium on BIS Values

Correlation Between Trend of Four Values and Bispectral Index Values During General Anaesthesia for Breast Surgery.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: University of Padova · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: —

Summary

Aim of this trial is to define if Trend of Four (TOF) values after a bolus of rocuronium is correlated with Bispectral Index BIS values during standard general anaesthesia for breast surgery.

Detailed description

Rocuronium. a curarizing agent, has been shown to decrease Bispectral Index (BIS) in awake volunteers. However, correlation between Trend of Four (TOF) values after a bolus of rocuronium and BIS values during general anaesthesia for breast surgery has not been defined yet. Investigators want to analyze this correlation during general anaesthesia conducted using Propofol and remifentanil. All of these drugs will be delivered with Targeted-Controlled Infusion pumps (in particular Eleveld for Propofol, Minto for Remifentanil), commonly used to deliver general anaesthesia. At stable anaesthesia maintenance, if requested for surgical (ie more muscle relaxation) or anesthesiological reasons (i.e. avoid air insufflation) a standard Rocuronium bolus (0.6 mg/kg) was given. In these case, with rocuronium bolus justified by clinical reasons, authors will observationally record the BIS values and the TOF values.

Conditions

• Breast Cancer
• General Anaesthesia

Interventions

Type	Name	Description
DRUG	Rocuronium	Rocuronium bolus was administered, according to our protocol, to facilitate surgery and ventilation.

Timeline

• Start date: 2023-03-03
• Primary completion: 2023-09-30
• Completion: 2023-09-30
• First posted: 2023-01-12
• Last updated: 2023-10-19

Locations

1 site across 1 country: Italy