Trials / Completed
CompletedNCT05680844
Peripheral Treg Cell Senescence & Serum Total Cholesterol Level
Observational Study of the Correlation Between Peripheral Treg Cell Senescence and Serum Total Cholesterol Level
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (actual)
- Sponsor
- Tianjin Medical University · Academic / Other
- Sex
- All
- Age
- 30 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
Hypercholesterolemia is a risk factor for the occurrence and development of atherosclerosis. Recent animal studies have found that increased serum cholesterol level is associated with peripheral Treg cell senescence, but clinical evidence is still lacking. The purpose of this study is to analyze the correlation between human peripheral Treg cell senescence and serum total cholesterol level using clinical blood samples, thus laying a foundation for the establishment of novel therapeutic strategies for atherosclerosis based on the regulation of Treg cell senescence.
Detailed description
Hypercholesterolemia is a risk factor for the occurrence and development of atherosclerosis. Recent animal studies have found that increased serum cholesterol level is associated with peripheral Treg cell senescence, but clinical evidence is still lacking. The purpose of this study is to analyze the correlation between human peripheral Treg cell senescence and serum total cholesterol level using clinical blood samples, thus laying a foundation for the establishment of novel therapeutic strategies for atherosclerosis based on the regulation of Treg cell senescence.
Conditions
Timeline
- Start date
- 2023-01-01
- Primary completion
- 2023-12-31
- Completion
- 2024-12-31
- First posted
- 2023-01-11
- Last updated
- 2025-04-08
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT05680844. Inclusion in this directory is not an endorsement.