Trials / Completed
CompletedNCT05678582
Hepatic Steatosis and Chronic Hepatitis B Virus
The Impact of Hepatic Steatosis on Chronic Hepatitis B Virus Infection
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 91 (actual)
- Sponsor
- Sohag University · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
This study aims to evaluate the prevalence and severity of hepatic steatosis in CHB and investigate the relationship between hepatic steatosis and viral load, liver biochemistry, liver fibrosis, and inflammation in CHB
Detailed description
This hospital-based cohort study will be conducted on 80 adult hepatitis B surface antigen (HBsAg) carriers presented to the Tropical Medicine and Gastroenterology outpatient clinic, at Sohag University Hospital Exclusion criteria Patients with serological evidence of HCV. HBV patients who had received or are currently under anti-viral therapy. Alcohol consumption. Decompensated liver disease. Patients with HCC. Patients are known to have another chronic liver disease (e.g. autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease, Haemochromatosis, or drug-induced chronic hepatitis). Patients with contraindications to liver biopsy such as uncooperative patients, prothrombin time (PT) \>4 seconds more than control, INR greater than 1.6, platelets count \<100.000/mm3After taking informed written consent, the participants will be subjected to: Clinical evaluation: medical history and physical examination. Laboratory investigations: Complete blood count. Prothrombin time and concentration. Liver function tests Anti-HCV. HBeAg. HBV DNA. Abdominal ultrasonography Ultrasound-guided percutaneous liver biopsy
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Liver biopsy | liver biopsy were taken then evaluated by histopathological examination |
Timeline
- Start date
- 2023-01-01
- Primary completion
- 2023-06-30
- Completion
- 2023-07-15
- First posted
- 2023-01-10
- Last updated
- 2023-07-21
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT05678582. Inclusion in this directory is not an endorsement.