NCT05677828

SMART Protocol vs Antagonist Protocol in IVF

Effect of the Addition of Letrozole in in Vitro Fertilization (IVF) Following a Prior Failed IVF Cycle With an Antagonist or Short Protocol Without Letrozole

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 426 (actual)
• Sponsor: Clinique Ovo · Industry
• Sex: Female
• Age: 20 Years – 42 Years
• Healthy volunteers: Not accepted

Summary

This retrospective study aims to assess the effect of adding letrozole in patients who have previously undergone an IVF cycle with either an antagonist or short protocol, with patients who have undergone a second cycle of IVF with an antagonist or short protocol without the addition of letrozole.

Detailed description

A limited number of studies suggest that the addition of letrozole to gonadotropins for IVF is associated with an increase in oocyte count, blastocyst count and implantation rate. These differences are presumed to be caused by an increase in intra-ovarian androgens associated with the addition of letrozole. In patients with reduced ovarian reserve or reduced oocyte quality in the previous cycle, supplementation with of letrozole has the potential to increase oocyte count or oocyte quality, thereby resulting in more transferable blastocysts. The antagonist stimulation protocol with the addition of letrozole is commonly referred to as the SMART protocol (Stimulation with Minimal Adverse effects, Retrieval and Transfer

Conditions

• Diminished Ovarian Reserve

Timeline

• Start date: 2022-02-15
• Primary completion: 2022-12-12
• Completion: 2023-01-31
• First posted: 2023-01-10
• Last updated: 2023-03-29

Locations

1 site across 1 country: Canada