NCT05677295

Therapeutic Efficacy in Women With Stress Urinary Incontinence

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy in Women With Stress Urinary Incontinence: a Randomized Controlled Study.

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Far Eastern Memorial Hospital · Academic / Other
• Sex: Female
• Age: 25 Years
• Healthy volunteers: Not accepted

Summary

We will get the impact of duloxetine versus imipramine on therapeutic efficacy in women with SUI.

Detailed description

Background/Purpose: Pharmacologic treatments for female stress urinary incontinence (SUI) include duloxetine and imipramine. Duloxetine and Imipramine has been reported to have clinical significant therapeutic efficacy on female SUI and overactive bladder syndrome. However, there was no randomized controlled study to compare duloxetine and imipramine for the treatment of female SUI. Patients and Methods: We will perform a prospective randomized controlled study to recruit 90 female SUI patients at the Obstetrics \& Gynecology outpatient clinic of Far Eastern Memorial Hospital. All SUI female patients will be asked to complete ICIQ-UI, USS, OABSS, and bladder diary before and after 4 weeks' duloxetine versus imipramine treatment.

Conditions

• Women With Stress Urinary Incontinence

Interventions

Type	Name	Description
DRUG	duloxetine	Duloxetine 30 mg per day
DRUG	Imipramine	Imipramine 25 mg per day

Timeline

• Start date: 2023-04-18
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2023-01-10
• Last updated: 2023-05-19

Locations

1 site across 1 country: Taiwan