NCT05674773

Treatment Outcomes of Advanced Neoplasia in IBD

Endoscopic and Surgical Treatment Outcomes of Colitis-associated Advanced Neoplasia: a Multicenter Cohort Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 189 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.

Detailed description

In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.

Conditions

• Inflammatory Bowel Diseases

Interventions

Type	Name	Description
PROCEDURE	Endoscopic or surgical resection	endoscopic or surgical (partial, (sub)total, proctocolectomy) resection

Timeline

• Start date: 2019-05-21
• Primary completion: 2022-12-31
• Completion: 2023-07-01
• First posted: 2023-01-06
• Last updated: 2023-01-06

Locations

1 site across 1 country: Netherlands