NCT05674396

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 108 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To learn if it is effective to use advanced radiation treatment techniques (stereotactic radiation or "SBRT") to safely deliver a strong dose of radiation to your tumor in a shorter period of time than would typically be feasible with traditional methods.

Detailed description

Objectives: * To compare local progression-free survival following palliation with SBRT versus traditional fractionations in patients with HN SCC deemed ineligible for curative-intent treatment. * To compare pain response, symptom burden, toxicity, local control, progression-free survival, and overall survival between the treatment modalities.

Conditions

• Head and Neck Squamous Cell Carcinoma

Interventions

Type	Name	Description
RADIATION	Stereotactic body radiotherapy	Participants will receive radiation as per the schedule discussed with the study doctor.
RADIATION	Traditional Palliation	Participants will receive radiation as per the schedule discussed with the study doctor.

Timeline

• Start date: 2023-06-30
• Primary completion: 2027-09-30
• Completion: 2027-09-30
• First posted: 2023-01-06
• Last updated: 2026-02-19

Locations

1 site across 1 country: United States