NCT05672381

NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome

Near-infrared Spectroscopic Tomography (NIRST) and ICG-based Perfusion Imaging to Diagnose and Assess Muscle Viability in High Energy Trauma at Risk for Acute Compartment Syndrome: A Pilot Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: Dartmouth-Hitchcock Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and deoxy-hemaglobin and water concentrations or ICG fluorescence signal, reflecting tissue perfusion, can be associated with development of Acute Compartment Syndrome and identification of at-risk soft tissue and muscle.

Conditions

• Compartment Syndromes
• Compartment Syndrome of Lower Leg
• Compartment Syndrome of Forearm

Interventions

Type	Name	Description
PROCEDURE	Lower extremity and/or upper extremity surgery	Lower extremity and/or upper extremity surgery

Timeline

• Start date: 2023-05-12
• Primary completion: 2025-09-16
• Completion: 2025-09-16
• First posted: 2023-01-05
• Last updated: 2025-10-06

Locations

1 site across 1 country: United States