NCT05671328

Incidence of Invasive Pulmonary Aspergillosis in Ventilator-associated Pneumonia

Evaluation of the Incidence of Invasive Pulmonary Aspergillosis in Patients With Suspected Ventilator-associated Pneumonia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 263 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Mechanically ventilated patients are at risk of developing ventilator-associated pneumonia (VAP). Invasive pulmonary aspergillosis (IPA), the diagnosis of which motivates the implementation of specific treatments, is one of the causes of VAP. The hypothesis of the study is that the incidence of IPA is 12.4%. For each patient presenting with a suspicion of VAP and requiring a bronchoalveolar lavage (BAL), the diagnosis of API will be evaluated by biological examinations performed on blood and BAL. Medical and surgical history as well as clinical and biological data will be collected for 28 days or until discharge from the ICU.

Conditions

• Ventilator Associated Pneumonia
• Pulmonary Aspergillosis Invasive

Interventions

Type	Name	Description
OTHER	Biological examinations performed on blood and BAL	Direct examination and culture of BAL Galactomannan in serum and BAL Serum 1,3 beta D glucans Aspergillus PCR in BAL

Timeline

• Start date: 2023-08-28
• Primary completion: 2025-07-18
• Completion: 2025-07-18
• First posted: 2023-01-04
• Last updated: 2025-12-26

Locations

1 site across 1 country: France