NCT05671289

Urine VOC Investigation in Bladder Cancer Diagnosis

Investigation of Urine Volatile Organic Compounds as Novel Diagnostic Biomarker in Bladder Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 77 (actual)
• Sponsor: First Affiliated Hospital Xi'an Jiaotong University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The goal of this study to investigate the volatile organic compounds (VOCs) in the urine samples of both healthy individual and bladder cancer patients, using gas chromatography - mass spectrometry. Researchers aim to find a set of certain VOCs specific to bladder cancer and use this set to construct a diagnostic model that can help diagnosing bladder cancer. Participants will be asked to collect their early morning midstream urine in a predesignated container. Researchers will compare urine VOCs from bladder cancer patients and healthy individuals to see if there is any VOC whose concentration differ significantly among the two groups.

Detailed description

Specifically, participants will be asked to collect 35-45 ml of their early morning midstream urine sample in a predesignated polytetrafluoroethylene bottle. Researcher will collect participants' health information, including their: 1)smoking history; 2)comorbidity; 3) history of past urological procedure; 4)medication; 5)pathology diagnosis after surgery, if participants have bladder cancer.

Conditions

• Bladder Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	analysis of urine volatile organic compounds	gas chromatography - mass spectrometry will be used to assess the composition of VOCs in urine samples of all participants.

Timeline

• Start date: 2022-11-10
• Primary completion: 2023-03-10
• Completion: 2023-03-10
• First posted: 2023-01-04
• Last updated: 2024-04-03

Locations

1 site across 1 country: China