NCT05671068

EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)

CEREBELLAR INVOLVEMENT IN MOTOR, COGNITIVE AND EMOTIONAL PROCESSES IN MYOCLONUS DYSTONIA

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 47 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 15 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Background: Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood. Objective: To investigate the neural correlates of cognition and emotion in DYT-SGCE. Design: Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours. Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI. Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.

Detailed description

Eligibility: DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.

Conditions

• Myoclonus-Dystonia
• DYT11

Timeline

• Start date: 2023-01-20
• Primary completion: 2024-02-19
• Completion: 2024-02-19
• First posted: 2023-01-04
• Last updated: 2026-01-23

Locations

1 site across 1 country: France