NCT05665478

Population Pharmacokinetics/Pharmacodynamics of Carbapenems in Febrile Neutropenia Patients

Dose Optimization of Carbapenem Antibacterials in Febrile Neutropenia Patients Based on PPK/PD Model and MAPB Method and Research on Individualized Drug Use Software

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

1. Evaluating the differences in the efficacy and safety of meropenem optimal dosing regimen predicted by the PPK/PD model combined with MAPB method for patients with malignant hematological myelopathy accompanied by fever, as compared with the current conventional treatment regimen; 2. The visualization software of meropenem individualized medication was developed with the help of JAVA development language, J2EE framework and SQL Server database.

Conditions

• Febrile Neutropenia
• Pharmacokinetics
• Pharmacodynamic
• Carbapenems

Interventions

Type	Name	Description
OTHER	Dose prediction using population pharmacokinetic models	Dose prediction using population pharmacokinetic models.

Timeline

• Start date: 2022-12-31
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2022-12-27
• Last updated: 2022-12-27