NCT05664295

Orexin-A Levels in Insomnia Patients

Comparison of Plasma Orexin-A Levels and Awakening Time From Anesthesia in Patients With and Without Insomnia Who Had Laparoscopic Cholecystectomy Under General Anesthesia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Muğla Sıtkı Koçman University · Academic / Other
• Sex: Male
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Detailed description

ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.

Conditions

• Insomnia
• Anesthesia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Jenkins Sleep Disorders scale and Epworth Sleepiness scale	Jenkins Sleep Disorders scale and Epworth Sleepiness scale

Timeline

• Start date: 2022-12-30
• Primary completion: 2023-01-30
• Completion: 2023-02-10
• First posted: 2022-12-23
• Last updated: 2023-03-15

Locations

1 site across 1 country: Turkey (Türkiye)