NCT05664035

SPAD in Adult Patients

Detection of Specific Polysaccharide Antibody Deficiency in Adult Patients With Unexplained Recurrent and/or Severe Bacterial Infections

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 99 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The DETECT study aims to demonstrate the importance of detecting SPAD in adult patients with recurrent benign and/or severe unexplained bacterial upper/lower respiratory tract infections. Unlike children in whom the deficit may be transient, long-term strategies are warranted in SPAD adult patients to prevent severe infections and lung disability. Beyond the diagnosis of this still unrecognized PID in adult patients, we want to assess the impact of prophylactic antibiotics or IgRT on infections prevention and on quality of life in adult patients with the most severe clinical phenotypes, recurrent infections with high frequency of antibiotics take and/or recurrent infections with complications like bronchiectasis and/or severe infections requiring hospitalizations.

Conditions

• Specific Antibody Deficiency
• Predominantly Antibody Deficiencies

Interventions

Type	Name	Description
BIOLOGICAL	Diagnosis of SPAD using immunization with PPV23	Diagnosis of SPAD using immunization with PPV23

Timeline

• Start date: 2023-03-01
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2022-12-23
• Last updated: 2022-12-23