NCT05661071

Neuropsychological Profiles of Children With Duchenne Muscular Dystrophy and Its Effects on Motor Functions

Determination of Neuropsychological Profiles of Children With Duchenne Muscular Dystrophy and Investigation of Its Effects on Motor Functions

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 74 (actual)
• Sponsor: Hacettepe University · Academic / Other
• Sex: Male
• Age: 7 Years – 16 Years
• Healthy volunteers: Accepted

Summary

This study was planned to determine neuropsychological profiles of children with Duchenne Muscular Dystrophy and investigation of its effects on motor functions \& compare to typically developed peers.

Detailed description

In this thesis, it is aimed to determine the neuropsychological profiles of children with Duchenne Muscular Dystrophy (DMD) and to investigate its effects on motor functions. The study will be carried out with children between the ages of 7 and 16 who have been diagnosed with DMD as a result of genetic testing and who applied to Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Pediatric Neuromuscular Diseases Unit for physiotherapy and rehabilitation evaluation. In addition, considering the primary purpose of the study, typically developed boys between the ages of 7 and 16 with similar physical characteristics will be included in the study and compared with children with DMD. Typically developed boys included in the study will be evaluated only with neuropsychological tests. Evaluating cognitive function from neuropsychological tests; Modified Mini Mental Test, The Controlled Oral Word Association Test,computer-based The Central Nervous System Vital Signs will be applied. To evaluate neurodevelopmental status from neuropsychological tests; Conners' Parent Rating Scale, Child Behavior Checklist, Strengths and Difficulties Questionnaire (SDQ) will be applied. To evaluate the motor functions of individuals with DMD; Brooke Lower Extremity Functional Classification, Motor Function Measurement, Four Square Step Test, Six Minutes Walk Test, Timed Performance Tests (10 meters Walk/Run Test, Gower's (from a supine to a standing position), Right/Left Leg Standing, Ascent/Descent of 4 Steps) will be used. In the study, in which the effect of the mutation region of dystrophin protein isoforms causing DMD on the neuropsychological profile of children will be investigated by comparing them with typically developed boys and the effect of this on motor function will be examined, the statistical significance level will be considered as p\<0.05

Conditions

• Duchenne Muscular Dystrophy

Interventions

Type	Name	Description
OTHER	Modified Mini Mental Test:	To assess the cognitive function of children
OTHER	The Controlled Oral Word Association Test	To assess the cognitive function of children
OTHER	The Central Nervous System Vital Signs	To assess the cognitive function of children
OTHER	Conners' Parent Rating Scale-48 (Parent Report)	To assess attention-deficit/hyperactivity disorder
OTHER	Child Behavior Checklist 6-18 ages (Parent Report)	To assesses both child adaptive behaviors and problem behaviors.
OTHER	Strengths and Difficulties Questionnaire (Self-Reported)	It is a brief emotional and behavioural screening questionnaire for children and young people.
OTHER	Brooke Lower Extremity Functional Classification	To determine the functional status of the lower extremity
OTHER	Motor Function Measurement-32 Items	To assessment of motor function and progression of weakness in neuromuscular disorders
OTHER	Four Square Step Test	A test of dynamic balance and coordination that clinically assesses the participant's ability to step over objects forward, sideways, and backwards.
OTHER	Six Minutes Walk Test	It evaluates the walking function and physical capacity of children at the submaximal level.
OTHER	Timed Performance Test	10 meters Walk\& Run Test, Gower's(from a supine to a standing position), Right\& Left Leg Standing, Ascent/Descent of 4 Steps

Timeline

• Start date: 2022-05-11
• Primary completion: 2023-03-01
• Completion: 2023-03-01
• First posted: 2022-12-22
• Last updated: 2022-12-22

Locations

1 site across 1 country: Turkey (Türkiye)