NCT05657470

Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)

Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK): a Prospective, Randomized, Open-label, Blinded End Point, and Multicenter Trial

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The best reperfusion strategy for medium-sized vessel occlusion (MeVO) is not well established. Given the proven treatment effect of intra-arterial thrombolysis in patients with large vessel occlusion (LVO), the investigators hypothesized that intra-arterial tenecteplase (TNK) could increase the recanalization rate of MeVO and thus improve clinical outcome. The current study aimed to explore the safety and efficacy of intra-arterial TNK in patients with MeVO.

Conditions

• Stroke, Ischemic

Interventions

Type	Name	Description
DRUG	Tenecteplase	intra-arterial tenecteplase

Timeline

• Start date: 2023-03-21
• Primary completion: 2025-06-16
• Completion: 2025-06-16
• First posted: 2022-12-20
• Last updated: 2025-06-17

Locations

1 site across 1 country: China