NCT05657457

Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT)

Improving Neurological Outcome for Acute Basilar Artery Occlusion With Sufficient Recanalization After Thrombectomy by Intraarterial Tenecteplase (INSIST-IT): a Prospective, Randomized, Open-label, Blinded-end Point, Multicenter Trial

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 145 (actual)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The potential benefit of intraarterial tenecteplase in acute basilar artery occlusion (BAO) patients with successful reperfusion following endovascular treatment (EVT) has not been studied. The current study aimed to explore the efficacy and safety of intraarterial tenecteplase in acute BAO patients with successful reperfusion after EVT.

Conditions

• Stroke, Ischemic

Interventions

Type	Name	Description
DRUG	Tenecteplase	intra-arterial tenecteplase

Timeline

• Start date: 2023-03-21
• Primary completion: 2025-05-18
• Completion: 2025-05-18
• First posted: 2022-12-20
• Last updated: 2025-07-02

Locations

1 site across 1 country: China