Trials / Unknown
UnknownNCT05654766
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
Development of a Method for Assessing the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies Using Flow Cytometry
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus · Other Government
- Sex
- All
- Age
- 1 Year – 17 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
Detailed description
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets using flow cytometry and turbidimetric and impedance aggregometry for use in the differential diagnosis of thrombocytopenia and platelet defects
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Flow cytometry | Parameters such as FSC, SSC, median fluorescence of anti CD42b, PAC-1, CD41, CD63, CD62P, as well as Annexin V fluorescence will be assessed. |
| DIAGNOSTIC_TEST | Platelet aggregation and plasma coagulation | Turbodimetric platelet aggregation test, impedance platelet aggregation test. Standard plasma coagulation test (fibrinogen level, prothrombin test, thrombin time, activated partial thromboplastin time (aPTT)). |
Timeline
- Start date
- 2023-01-02
- Primary completion
- 2024-12-01
- Completion
- 2024-12-31
- First posted
- 2022-12-16
- Last updated
- 2022-12-16
Source: ClinicalTrials.gov record NCT05654766. Inclusion in this directory is not an endorsement.