NCT05653141

Post-stroke Cognitive Impairment

Prediction of Post-stroke Cognitive Decline and Dementia: Impact of Cognitive Reserve and Post-stroke Life Style

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 335 (estimated)
• Sponsor: Roza Umarova · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.

Detailed description

The study aim is to establish a model capturing patients' inter-individual variability in susceptibility to stroke damage to predict stroke-induced cognitive trajectories. This is a prospective longitudinal observational national monocentric study for 6 years (recruitment during the first 3 years). The investigators perform comprehensive neuropsychological testing in i) acute stroke phase (0-10 days post-stroke), ii) sub-acute stroke phase (3 months post-stroke), and iii) chronic stroke phase (12 months and 3 years post-stroke). At each time point, cognitive performances as well as clinical and functional status will be assessed. Furthermore, the investigators will assess the proxies of cognitive reserve and the level of post-stroke physical activity.

Conditions

• First-ever Ischemic Stroke
• Cognitive Performance

Timeline

• Start date: 2020-12-17
• Primary completion: 2026-10-31
• Completion: 2026-10-31
• First posted: 2022-12-16
• Last updated: 2024-11-13

Locations

1 site across 1 country: Switzerland