NCT05651529

Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?

Does Oral Intake of Beta-hydroxybutyrate Decrease Left Ventricular End-systolic Volume at Cardiac Magnetic Resonance in Patients With Heart Failure Compared to Carbohydrate Placebo?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?

Detailed description

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt in heart failure condition. Participants will have 2 different cardiac MRI to perform: 1. Fasting with exogenous ketone salt supplement 2. Fasting with exogenous carbohydrate supplement

Conditions

• Heart Failure

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	exogenous ketone salt supplement	Dietary Supplement: Fasting water and with exogenous ketone salt supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.
DIETARY_SUPPLEMENT	exogenous carbohydrate supplement	Dietary Supplement: Fasting water and with exogenous carbohydrate supplement. Participants will have to take 1 doses of supplement 30 minutes before the scan.

Timeline

• Start date: 2022-12-16
• Primary completion: 2025-12-16
• Completion: 2025-12-16
• First posted: 2022-12-15
• Last updated: 2026-01-07

Locations

2 sites across 1 country: Canada