NCT05651243

Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

Non-pharmacological Treatments for Obesity: Leveraging the Appetite Suppressive Effects of Hyperketonemia Through Exogenous Ketone Ingestion to Treat Obesity, Insulin Resistance, and Cognition

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Southern Mississippi · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The goal of this single-blind randomized placebo-controlled trial is to test the effects of an oral ketone supplement on appetite, cognition, metabolism, and cardiovascular function in individuals with obesity and insulin resistance. The main question\[s\] it aims to answer are: * Does taking the ketone supplement reduce appetite and improve cognition? * How does the ketone supplement alter metabolism and cardiovascular function? Participants will be asked to consume a randomly assigned ketone ester supplement or a placebo and testing will be done to see how the supplement affects the following compared to a placebo: * appetite, * cognition, * metabolism * cardiovascular function Researchers will compare individuals with obesity and insulin resistance to individuals with normal weight and no insulin resistance to see if the ketone supplement affects groups differently.

Conditions

• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone Ester Supplement	Oral ingestion of a ketone supplement combined with a flavoring agent and diluted in water
OTHER	Placebo	Oral ingestion of cellulose combined with a flavoring agent and diluted in water

Timeline

• Start date: 2022-12-28
• Primary completion: 2023-12-29
• Completion: 2023-12-29
• First posted: 2022-12-14
• Last updated: 2024-05-22

Locations

1 site across 1 country: United States