NCT05650827

Feasibility and Effect of Resistance Training and Protein Supplementation in Patients With Advanced Gastroesophageal Cancer

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with advanced gastroesophageal cancer are in great risk of losing skeletal muscle mass and developing cancer cachexia. Low skeletal muscle mass has a negative impact on quality of life, impairs physical function, increases toxicity from anti-neoplastic treatment, as well as increases risk of death. Resistance training and protein supplements have the potential to stimulate muscle anabolism and counteract loss of skeletal muscle mass. Therefore, the investigators have designed a randomized controlled feasibility trial to evaluate the feasibility, safety and the therapeutic effect of resistance training and protein supplements in patients with advanced gastroesophageal cancer undergoing first line chemotherapy. A total of 54 patients with advanced gastroesophageal cancer will be recruited from the Department of Oncology, Copenhagen University Hospital, Rigshospitalet and randomly allocated 2:1 to standard care plus resistance training 3 times pr. week and a daily supplement of protein or to standard care alone.

Conditions

• Gastro-esophageal Cancer

Interventions

Type	Name	Description
BEHAVIORAL	Resistance training	10 weeks of resistance training 3 times pr. week.
DIETARY_SUPPLEMENT	Protein supplement	A daily supplement of protein to ensure a daily intake of 1,6g protein/kg bodyweight

Timeline

• Start date: 2023-02-24
• Primary completion: 2024-12-31
• Completion: 2027-12-31
• First posted: 2022-12-14
• Last updated: 2025-05-14

Locations

1 site across 1 country: Denmark