NCT05650151

Peri-operative Vitamin D Therapy for Hepatectomy

Peri-operative Vitamin D Therapy for Patients With Hepatocellular Carcinoma Receiving Hepatectomy

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: National Taiwan University Hospital · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The goal of this double-blind, randomized controlled trial is to test the effect of short-term and high-dose vitamin D therapy in patients undergoing hepatectomy for hepatocellular carcinoma.

Detailed description

Participants will receive short-term high dose of vitamin D during perioperative period. The main questions the study aims to answer are: 1. If vitamin D therapy benefits perioperative care 2. If short-term high dose of vitamin D supplement is safe

Conditions

• Vitamin D Deficiency
• Hepatocellular Carcinoma
• Perioperative Complication

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Vitamin D	576 000 IU D 5-7 days prior to the surgery and 144 000 IU daily on post-operative day 1-2
DIETARY_SUPPLEMENT	Placebo	An equal volume of medium chain triglyceride (MCT, as placebo) to vitamin D 5-7 days prior to the surgery and on the post-operative day 1-2.

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-12-31
• Completion: 2024-01-31
• First posted: 2022-12-14
• Last updated: 2022-12-14