NCT05646810

Impact of Peripheral Afferent Input on Central Neuropathic Pain

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.

Detailed description

A key question that has been subject to longstanding debates in the field relates to the sites and mechanisms within the peripheral or central nervous system that potentially perpetuate chronic spontaneous and evoked central neuropathic pain. The investigators hypothesize that spontaneous central neuropathic pain depends on continuous, "physiological" somatosensory input from the painful body region in the periphery. Thus, spontaneous central neuropathic pain results from pathological gain control in central somatosensory networks with decreased activation thresholds for thermo- and mechanosensitive peripheral afferents.

Conditions

• Spinal Cord Injuries
• Spinal Cord Diseases
• Syringomyelia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Lidocaine (10 mg/ml)	Lidocaine (10 mg/ml) will be injected according to established protocols using ultrasound guidance and an aseptic technique by an experienced anesthesiologist.
DIAGNOSTIC_TEST	Isotonic saline	Isotonic saline will be injected according to established protocols using ultrasound guidance and an aseptic technique by an experienced anesthesiologist.

Timeline

• Start date: 2022-12-01
• Primary completion: 2023-09-30
• Completion: 2023-12-31
• First posted: 2022-12-12
• Last updated: 2022-12-12