NCT05645185

Characterisation of Clinical Phenotypes and Outcomes of Ma2 Patient

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 43 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Paraneoplastic neurological syndromes (PNS) are rare complications of cancer occurring in 0.01% of cases. Their clinical, biological and radiological presentation is heterogeneous and may constitute a diagnostic challenge. Anti-Ma2 PNS are rare diseases with a guarded prognosis. They are most often associated with a seminoma-like testicular tumor but can also be associated with lung cancer. Classically, they present as limbic, diencephalic and/or brainstem encephalitis. Anti-Ma2 antibodies target intracellular receptors and are characteristic of a particular form of encephalitis. Atypical manifestations including narcolepsy-cataplexy, weight gain, sexual dysfunction and motor neuron syndrome have been described and explain the difficulty in diagnosing anti-Ma2 associated PNS. It seems interesting to better characterize the phenotypes of Ma2 patients in order to optimize the diagnosis and follow-up.

Conditions

• Autoimmune Encephalitis
• Paraneoplastic Syndromes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Diagnosis test	Tests can be used: immunofluorescence, immunodot, western blot, tests CBA on sera or CSF.

Timeline

• Start date: 2021-10-01
• Primary completion: 2022-03-01
• Completion: 2022-10-01
• First posted: 2022-12-09
• Last updated: 2022-12-09

Locations

1 site across 1 country: France