NCT05645081

Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

PREDICT-EV; the Association of Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 360 (estimated)
• Sponsor: Cwm Taf University Health Board (NHS) · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Annually 100,000 strokes occur, placing stroke as the largest cause of disability in the UK. 90% of strokes are preventable, leading to national focus on programmes including "The National Stroke Programme" to act on preventing, treating, and improving post-stroke care. Importantly, over 25% of ischaemic stroke sufferers have previously had a Transient Ischaemic Attack (TIA), which presents the biggest concern for TIA patients. There are no measures which reliably identify TIA patients most likely to suffer a stroke. Novel biomarkers for predicting stroke are key to addressing this problem. The PREDICT-EV study aims to screen 300 TIA patients and follow them over 12-months. The investigators will determine if a novel biomarker we've identified to increase thrombotic risk (endothelial derived extracellular vesicles) and the resulting increased prothrombin time is associated with patients at highest risk of stroke.

Conditions

• Stroke, Ischemic
• Transient Ischemic Attack
• Coagulation Disorder

Timeline

• Start date: 2021-10-01
• Primary completion: 2026-09-01
• Completion: 2027-09-01
• First posted: 2022-12-09
• Last updated: 2024-08-20

Locations

1 site across 1 country: United Kingdom