NCT05642104

The Detection of Cell-in-cell Structure (CICs) in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 175 (estimated)
• Sponsor: Beijing Shijitan Hospital, Capital Medical University · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Breast cancer is the most common malignant tumor in women worldwide and neoadjuvant therapy has been the standard care for local advanced breast cancer. Moreover, neoadjuvant therapy undoubtedly provides an ideal model to evaluate the response to therapy. Cell-in-cell structures (CICs) refer to the presence of one or more cells inside host cell, which generally leads to the death of inner cells. Notably, established evidences indicated that CICs were present in breast cancer and tend to impact patient survival. However, whether CICs profile could predict efficacy of therapy remains unclear. In this prospective cohort study, the CICs number and profile will be detected in tumor tissue before and after the neoadjuvant therapy. Then the association between CICs number including dynamic changing and response rate will be explored.

Conditions

• Breast Neoplasms

Interventions

Type	Name	Description
DRUG	Neoadjuvant therapy	all procedures is in accordance with international guidelines and domestic expert consensus on breast cancer.

Timeline

• Start date: 2021-10-01
• Primary completion: 2023-10-01
• Completion: 2024-10-01
• First posted: 2022-12-08
• Last updated: 2022-12-08

Locations

1 site across 1 country: China