NCT05639283

Primary Obstructive Megaureter Management in Eastern Interregional Area

Primary Obstructive Megaureter Management in Eastern Interregional Area : Current Status and Perspectives

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 1 Year – 17 Years
• Healthy volunteers: Not accepted

Summary

Congenital obstructive megaureter is a urinary malformation affecting the ureterovesical junction and causing obstruction to the flow of urine. It is the second most common cause of hydronephrosis. This malformation affects four times more boys than girls and is bilateral in 25% of cases. It is also associated with contralateral renal dysplasia in 15% of cases. The obstruction is linked to aperistalsis and hypertrophy of the circular muscle bundles and increased collagen 1 level. This malformation is accessible to antenatal screening from the second trimester. It falls within the scope of CAKUT and requires regular monitoring. Indeed, this uropathy can cause repeated pyelonephritis, kidney scarring and affected kidney function.

Conditions

• Congenital Obstructive Megaureter

Timeline

• Start date: 2020-09-02
• Primary completion: 2022-03-02
• Completion: 2022-03-31
• First posted: 2022-12-06
• Last updated: 2023-12-08

Locations

1 site across 1 country: France